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Home - Products - GPCR/G Protein - Orexin Receptor - SB-334867 free base

SB-334867 free base

CAS No. 792173-99-0

SB-334867 free base( SB334867A free base | SB334867 free base | SB 334867 free base )

Catalog No. M15972 CAS No. 792173-99-0

The first selective Orexin-1 receptor antagonist with pKb of 7.4.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 61 Get Quote
10MG 95 Get Quote
25MG 199 Get Quote
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Biological Information

  • Product Name
    SB-334867 free base
  • Note
    Research use only, not for human use.
  • Brief Description
    The first selective Orexin-1 receptor antagonist with pKb of 7.4.
  • Description
    The first selective Orexin-1 receptor antagonist with pKb of 7.4; displays 50-fold selectivity over OX2 (pKb 5.7), >100-fold or selectivity over 5-HT2B, 5-HT2C and approximately 50 other molecular targets, in particular GPCRs and ion channels; possesses CNS penetration, in vivo activity following ip dosing.Obesity Preclinical.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Swiss mice Dosage:20?mg/kg Administration:Intraperitoneal injectionResult:Inhibited the acquisition of morphine-induced sensitization to locomotor activity of mice.Animal Model:C57BL/6J Mice Dosage:3, 10 and 30 mg/kg Administration:Intraperitoneal injectionResult:Reduced ethanol consumption, BECs and suppressed sucrose intake in mice.
  • Synonyms
    SB334867A free base | SB334867 free base | SB 334867 free base
  • Pathway
    GPCR/G Protein
  • Target
    Orexin Receptor
  • Recptor
    OX1
  • Research Area
    Metabolic Disease
  • Indication
    Obesity

Chemical Information

  • CAS Number
    792173-99-0
  • Formula Weight
    319.3174
  • Molecular Formula
    C17H13N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 49 mg/mL
  • SMILES
    CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4
  • Chemical Name
    Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Smart D, et al. Br J Pharmacol. 2001 Mar;132(6):1179-82. 2. Porter RA, et al. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1907-10. 3. Rodgers RJ, et al. Eur J Neurosci. 2001 Apr;13(7):1444-52.
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